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CNS Pharmacology

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Question:

Adverse effect ssri

Author: Suzuki



Answer:

Headache, sweating, anxiety and agitation, gastrointestinal (GI) effects (nausea, vomiting, diarrhea), weakness and fatigue, sexual dysfunction, changes in weight, sleep disturbances (insomnia and somnolence), and the above-mentioned potential for drug-drug interactions. Sleep disturbances: Paroxetine and fluvoxamine are generally more sedating than activating, and they may be useful in patients who have difficulty sleeping. Sexual dysfunction: Loss of libido, delayed ejaculation, and anorgasmia are underreported side effects often noted by clinicians, but these are not prominently featured in the list of standard side effects.Extrapyramidal effects early in treatment may include akathisia, dyskinesias, and dystonic reactions. Seizures are a consequence of gross overdosage. Cardiac effects of citalopram overdose include QT prolongation. A withdrawal syndrome has been described for SSRIs, which includes nausea, dizziness, anxiety, tremor, and palpitations.


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Suzuki
Suzuki