PHARMCARE 3
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The use of traditional compounding techniques to manipulate chemical ingredients to produce appropriate dosage forms when no commercial medicine form is available | Extemporaneous compounding |
Quality control FOR 1 Oral and topical liquids 2 Hard gelatin capsules | . 1 pH, sp. Gravity, assays, rheological properties, physical observation, physical stability 2 weight variation, dissolution and disintegration |
Quality control FOR 1 Ointments, creams and Gels 2 Suppositories, Trouches | . 1 pH, sp. Gravity, assay, rheological properties 2 melting points, dissolution test, physical stability |
Quality control FOR 1 Parenteral Preparation | . 1 pH, sp. Gravity, osmolality, color, clarity, particulate matter, sterility |
Should be developed or obtained Methods used, ingredients added and order of steps is documented. | Formulas |
Proper dispensing container for the medications Pharmaceutical-grade chemical is necessary Pharmacist use different chemicals from reliable sources | Chemical and Supplies |
Risks associated with extemporaneous compounding: | 1 Formulation Failure 2 Microbial contamination 3 Calculation errors 4 Starting materials 5 Patient Accessibility issues 6 Health and Safety Risk 7 Therapeutic risks and clinical consequences |
1 This is an ideal surface for mixing compounds because of its nonabsorbent surface. 2 The coarser the surface, the finer the triturating, or grinding, that can be done. 3 used for measuring liquids with a volume less than 1.5 mL | 1 Compounding Slab 2 Mortar and Pestle 3 Graduates and Pipettes |
Prepared by the pharmacist, this sheet indicates the amount of each ingredient needed, lists the procedures to follow, and provides the labeling instructions. | Master Formula Sheet |
Is one of the most essential parts of the compounding process. | Weighing of the product |
A way to combine drugs using a mortar and pestle. | Geometric Dilution Method |
Principles of Medication Review | 1. All patients should have a CHANCE TO RAISE QUESTIONS and highlight problems about their medicines. 2. Medication review SEEKS TO IMPROVE OR OPTIMIZE impact of TREATMENT for a patient 3. The review is undertaken in a SYSTEMATIC WAY, by a competent person 4. Any CHANGES resulting from the review are AGREED WITH THE PATIENT 5. The review is DOCUMENTED in the patient’s notes 6. The impact of any change is MONITORED |
Type of Medication review | Type 1: Prescription Review Type 2: Concordance and Compliance Review Type 3: Clinical Medication Review PCC |
Review Process | 1. Identify patients 2. Carry out the review 3. Record review outcomes / Feedback results 4. Audit / Quality assurance ICRA |
Medication review may initially need to be prioritized to patients who are __ | At risk of medicine related problems. |
(Carrying out the review) Ten-point medication review | 1 Why is this patient taking this drug? 2 Is the reason clear from the history summary? 3 Is the patient capable of taking this drug and is compliance satisfactory? 4 Are any tests required to monitor side-effects or dosage? 5 Are there any potential drug interactions and are they of significance? 6 What would happen if the drug was stopped? 7) Does the repeat need to be continued for the next 6 or 12 months? 8)Are any non-repeat items being prescribed regularly? 9 Should these be converted to formal repeats? 10 Set a date for the next review? |
Recording the review outcomes | Level 1: REVIEW OF A LIST OF THE MEDICATION under the direction of doctor, nurse or pharmacist, but in the ABSENCE OF THE PATIENT Level 2: TREATMENT REVIEW UNDER THE direction of a doctor, nurse or pharmacist, in the ABSENCE OF THE PATIENT but with REFERENCE to the CODING ONLY PATIENT’S CLINICAL RECORD Level 3: CLINICAL MEDICATION REVIEW specifically undertaken by a doctor, nurse or pharmacist in the PRESENCE OF THE PATIENT with ACCESS to the PATIENT’S CLINICAL RECORD and LABORATORY TEST RESULTS as required |
Who does the Review? | In practice doctors, pharmacists and many nurses have the clinical skills and therapeutic knowledge to perform all aspects of medication review |
(What should the review cover? ) For each drug: Check that: | 1 The medication prescribed is APPROPRIATE for the patient’s needs 2 The medication is EFFECTIVE for the patient 3 The medication is a COST EFFECTIVE choice 4 Any required MONITORING has been done or arrangements are in place |
The NO TEARS Mnemonic to Aid Medication Review in a 10 Minute Consultation 10 | N Need and Indication O Open Questions T Tests and Monitoring E Evidence and Guidelines A Adverse Events R Risk reduction or prevention S Simplification and switches |
Type 3: Clinical Medication Review When to do it? | Patient’s with long-term conditions Patient with recently diagnose long-term conditions Patient experienced an adverse event associated with medicine-taking Patient/Carer requests a review or reports they have stopped taking prescribed medicine. |
Type 1: Prescription Review When to do it? | 1 Patient’s with long-term conditions 2 Patient with recently diagnose long-term conditions 3 Patient experienced an adverse event associated with medicine-taking 4 Patient/Carer requests a review or reports they have stopped taking prescribed medicine. |
Type 1: Prescription Review When to do it? | 1 Patient is IN THE HOSPITAL or TRANSFERRED BETWEEN CARE SETTINGS 2 REVIEWING PRACTICE for a class of medicine |
Type 2: Concordance and Compliance Review When to do it? | 1 PATIENT IS DISCHARGED from the hospital 2 Patient has NEW MEDICINE 3 Patients with LONG TERM CONDITIONS WITH MULTIPLE MEDICATIONS 4 Clinician IDENTIFIED a MEDICATION RELATED PROBLEM |
Type 3: Clinical Medication Review When to do it? | 1 Patient’s with LONG-TERM CONDITIONS 2 Patient with RECENTLY DIAGNOSE LONG-TERM CONDITIONS 3 Patient experienced an ADVERSE EVENT ASSOCIATED WITH MEDICINE-TAKING 4 Patient/Carer REQUESTS A REVIEW OR REPORTS they have STOPPED TAKING PRESCRIBED MEDICINE. |
Is the ONE OF THE MOST IMPORTANT FACTORS that determines the therapeutic out comes, especially in a patient suffering from chronic illness/diseases. | Medication adherence |
A person is classified as __ if he or she never fills a prescription or stops taking a prescription prematurely. | Non-persistent |
Types of Non-adherence | 1 Non-fulfillment 2 Non-persistence 3 Non-conforming |
Non-fulfillment give examples | 1 Prescription is never filled |
Non-persistence give examples | - Px stopped taking the medication after taking it rarely intentional (due to miscommunication, reduced capacity, etc) |
Non-conforming give examples | 1 Medication is not taken as prescribed 2 Missed doses, Incorrect doses, Dose taken at the wrong time |
“poor medication taking behavior due to circumstances BEYOND THE PATIENT’S CONTROL, such as socioeconomic issues, carelessness, forgetfulness and cognitive impairment” | Unintentional Nonadherence |
Adherence is a multidimensional phenomenon determined by the interplay of FIVE SETS OF FACTORS, termed "DIMENSIONS" by the World Health Organization: In simple terms: GIVE FIVE SET OF FACTORS OF ADHERENCE | 1. Social/economic factors 2. Provider-patient/health care system factors 3. Condition-related factors 4. Therapy-related factors 5. Patient-related factors SP CTP |
1. SOCIAL AND ECONOMIC DIMENSION give examples | 1 limited english proficiency 2 low health literacy 3 lack of family and social support network 4 unstable living conditions 5 burdensome schedule 6 limited access to healthcare facilities 7 lack of health care insurance 8 inability/difficulty accessing pharmacy 9 medication cost 10 cultural and lay beliefs 11 elder abuse |
THERE ARE SEVERAL WAYS TO MEASURE MEDICATION ADHERENCE. | 1. Medication Event Monitoring Systems (MEMS) - the most accurate 2. Patient self-reports - easiest method 3 Pill Counts 4 Pharmacy databases or Refill rates 5 Blood levels 6 Morisky's Medication Adherence Scale (MMAS) 2M3PB |
HEALTH CARE SYSTEM DIMENSION give examples | 1 provider-patient relationship 2 provider communication skills 3 disparity between the health beliefs of the health care provider and those of the patient 4 lack of positive reinforcement from healthcare provider 5 weak capacity of the system to educate px and follow up 6 lack of knowledge on adherence and of effective interventions for improving it 7 px information materials written at high literacy level 8 restricted formularies; changing meds covered on formularies 9 high drug cost 10 poor access or missed appointments 11 long wait times 12 lack of continuity of care |
These are the MOST ACCURATE method of measuring adherence because they record the date and time the medication bottle was OPENED THROUGH MICROPROCESSOR technology embedded in the cap. (GIVE THE disadvantages of this) | Medication Event Monitoring Systems (MEMS) Disadvantages: 1 erroneous/not faith/falls., because pt may remove more than one dose 2 Very expensive & different devices are needed for each medication 3 Therefore it is an impractical way to determine adherence in clinical practice. |
CONDITION-RELATED DIMENSION give examples | 1 chronic 2 lack of symptoms 3 severity of symptoms 4 depression 5 psychotic disorders 6 mental retardation/ developmental disability |
Methods that can improve Medication Adherence by Pharmacists iisa ang method | 1 Improve PHARMACY WORKFLOW 2 SIMPLIFY Patient’s Medications 3 IDENTIFY REASONS for Medication Non-adherence 4 ASK PATIENTS SPECIFIC QUESTIONS about their Medication IISA |
ROLE of Pharmacists in ADHERENCE | 1 PX education 2 Dosing simplification & minimization of A/E 3 Preparing a dosing card PDP |
1. SOCIAL AND ECONOMIC DIMENSION give examples | 1 LIMITED ENGLISH PROFICIENCY 2 LOW HEALTH LITERACY 3 LACK OF FAMILY AND SOCIAL SUPPORT NETWORK 4 UNSTABLE LIVING CONDITIONS 5 burdensome schedule 6 LIMITED ACCESS to healthcare facilities 7 lack of health care insurance 8 inability/DIFFICULTY ACCESSING PHARMACY 9 MEDICATION COST 10 cultural and lay beliefs 11 elder abuse |
HEALTH CARE SYSTEM DIMENSION give examples | 1 PROVIDER-PATIENT RELATIONSHIP 2 PROVIDER COMMUNICATION SKILLS 3 disparity between the health beliefs of the health care provider and those of the patient 4 LACK OF POSITIVE REINFORCEMENT from healthcare provider 5 WEAK CAPACITY of the system TO EDUCATE PX AND FOLLOW UP 6 LACK OF KNOWLEDGE ON ADHERENCE and of effective interventions for improving it 7 px information materials written at HIGH LITERACY LEVEL 8 restricted formularies; changing meds covered on formularies 9 HIGH DRUG COST 10 POOR ACCESS OR MISSED APPOINTMENTS 11 LONG WAIT TIMES 12 LACK OF CONTINUITY OF CARE |
CONDITION-RELATED DIMENSION give examples | 1 chronic 2 lack of symptoms 3 severity of symptoms 4 depression 5 psychotic disorders 6 mental retardation/ developmental disability |
THERAPY-RELATED DIMENSION give examples | 1 COMPLEX MEDICATION REGIMEN 2 TREATMENT REQUIRES MASTERY of certain techniques 3 DURATION OF THERAPY 4 FREQUENT CHANGES IN MED REGIMEN 5 LACK OF IMMEDIATE BENEFIT OF THERAPY 6 medications with SOCIAL STIGMA attached use 7 ACTUAL OR PERCEIVED UNPLEASANT SIDE EFFECTS 8 TREATMENT INTERFERES WITH LIFESTYLE or requires significant behavioral changes |
PATIENT-RELATED DIMENSION give examples | PHYSICAL FACTORS - visual, hearing, cognitive, mobility impairment - swallowing problems PSYCHOLOGICAL/BEHAVIORAL FACTORS - knowledge about dx - perceived risk - understanding reason meds is needed - attitude toward treatment - confidence in ability to follow treatment regimen - motivation - fear of possible a/e - fear of dependence - feeling stigmatized by the dx - frustration w/ health care providers - stress, anxiety - alcohol or susbtance use |
Why is Pharmaceutical Care Important? | 1 MULTIPLE PRESCRIBERS 2 EXPLOSION DRUG PRODUCTS AND DRUG INFORMATION 3 Increase COMPLEXITY OF DRUG THERAPY 4 Significant level of DRUG-RELATED MORBIDITY AND MORTALITY 5 HIGH FINANCIAL COST of drug misadventure 6 Social NEED TO ADDRESS DRUG-RELATED PROBLEMS (DRP) MEI SHS |
Primary Responsibilities of Pharmacist | A. To ensure patient’s drug therapy is safe, effective and efficient b. To identify, resolve, and prevent any DRPs c. To ensure that the patient’s therapeutic goals are met and optimal health-related outcomes are attained |
Definite Outcomes 1 requires an assessment of what has been achieved against what was expected 2 Outcomes of drug tx must be assessed against __ 3 there is an ↑ striving for better ways of measuring and __ | . 1 careful optimization of drug therapy 2 definite goals 3 recording clinical outcomes |
Definite Outcomes 1 __ requires an assessment of what has been ACHIEVED against what was EXPECTED | . 1 careful optimization of drug therapy |
Drug Therapy 1 process of securing __ from drug therapy is becoming increasingly complex- patients may receive medication unnecessarily 2 __ are made under circumstances in which patients are not fully informed or involved-> patient should be part of that decision if they do require medication | . 1 best results 2 decisions to start, to continue, to change or discontinue a drug |
Drug Therapy 1 concept of MEETING INDIVIDUAL PATIENT’S PARTICULAR NEEDS 2 Securing __ in decision making and in monitoring patient’s progress are important objectives in pharmaceutical care. | . 1 “optimization” 2 patient’s commitment and ensuring continuity |
Drug Therapy 1 Objectives 2 Outcome | . 1 > Cure > Reduce or eliminate symptom > Slow down disease progression > Prevention 2 > ↑ pt. quality of life/wellbeing > ↑ work productivity > Save cost |
Pharmaceutical Care Process | 1 Collect 2 Assess 3 Plan 4 Implement 5 Monitor 6 Follow Up CAPtain IMF |
Constructing PCP | 1. IDENTIFY THE PHARMACEUTICAL CARE ISSUES >”medical-related problems” ex. Uncontrolled BP, irregular home glucose monitoring, non-compliance to diet 2. PRIORITIZE the care issues 3.Determine the ACTION to be taken 4. RECORD the action taken 5. Record the OUTCOME of the action taken IP DRR |
Various ways to document patient care & PCP | A. SOAP format b. FARM format c. “IAO” (care issues, action, outcome) format |
Challenges in Pharmaceutical Care | 1. Knowledge and skills update 2. Communication with patient 3. Communication with doctors 4. Time management KCC Ta |
SOAP Format Includes: > Medical problems (diagnosis) > DRPs > Clinical progress ( ex. Gastritis- resolved) | A= Assessment |
“IAO” Format | >I= care issues similar to A in the SOAP > A= action (“pharm care action”) similar to P in the SOAP > O= outcome To document the outcome of the action carried out |
A __ is anything involving drug therapy that interferes with (or has the potential to interfere with) the desired outcome for a patient. - PCNE | Medication-related problem |
TYPES OF MEDICATION RELATED PROBLEMS | 1 Meds requires NEW or ADDITIONAL DRUG THERAPY that is NOT PRESCRIBED 2 Patient is taking UNNECESSARY DRUG 3 WRONG DRUG for patients condition or age 4 patient NOT TAKING DRUG CORRECTLY 5 CORRECT DRUG, DOSE TOO LOW 6 CORRECT DRUG, DOSE TOO HIGH 7 ADVERSE DRUG REACTION / DRUG INTERACTION |
How to Prevent? MRPs | 1 Communicate effectively with health care providers about medications. 2 Designate a medication manager. 3 Keep a medication list. 4 Consult with a doctor or pharmacist before taking over-the-counter medication, alcohol or herbal supplements along with prescription drugs. 5 Use common sense when using medications. 6 Obtain medication refills in a timely manner. |